Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party
نویسندگان
چکیده
David Grimwade, Andrea Biondi, Marie-Joëlle Mozziconacci, Anne Hagemeijer, Roland Berger, Michael Neat, Kathy Howe, Nicole Dastugue, Joop Jansen, Isabelle Radford-Weiss, Francesco Lo Coco, Michel Lessard, Jesus-Maria Hernandez, Eric Delabesse, David Head, Vincenzo Liso, Danielle Sainty, Georges Flandrin, Ellen Solomon, Françoise Birg, and Marina Lafage-Pochitaloff, on behalf of Groupe Français de Cytogénétique Hématologique, Groupe Français d’Hématologie Cellulaire, UK Cancer Cytogenetics Group, and BIOMED 1 European Community-Concerted Action “Molecular Cytogenetic Diagnosis in Haematological Malignancies”
منابع مشابه
The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran
Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML). Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran. Methods: Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was ...
متن کاملAcute Promyelocytic Leukemia Lacking the Classic Translocation t(15;17)
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) characterized by the reciprocal translocation t(15;17)(q22;q12) resulting in the fusion gene PML-RARA and an oncoprotein that impairs myeloid differentiation (Arber et al., 2008; de The et al., 1990; Rowley et al., 1977). Morphological and clinical characteristics include hypergranular leukemic promyelocytes, Auer r...
متن کاملA new morphologic classification system for acute promyelocytic leukemia distinguishes cases with underlying PLZF/RARA gene rearrangements.
Acute promyelocytic leukemia (APL) is typified by the t(15;17) translocation, which leads to the formation of the PML/RARA fusion gene and predicts a beneficial response to retinoids. However, approximately 10% of all APL cases lack the classic t(15;17). This group includes (1) cases with cryptic PML/RARA gene rearrangements and t(5;17) that leads to the NPM/RARA fusion gene, which are retinoid...
متن کاملBiphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor α Rearrangement
Biphenotypic acute leukemias (BAL) account for less than 4% of all cases of acute leukemia. Philadelphia chromosome and 11q23 rearrangement are the most frequently found cytogenetic abnormalities. Since t(15;17) is almost always associated with acute promyelocytic leukemia, t(15;17) in BAL cases is extremely uncommon. We report here a rare and instructive case of BAL with t(15;17) and the succe...
متن کاملAcute promyelocytic leukemia with the translocation t(15;17)(q22;q21) associated with t(1;2)(q42~43;q11.2~12): a case report
BACKGROUND Acute promyelocytic leukemia is characterized by a typical reciprocal translocation t(15;17)(q22;q21). Additional chromosomal abnormalities are reported in only 23-43 % of cases of acute promyelocytic leukemia. CASE PRESENTATION Here we report the case of a 46-year-old Syrian Alawis woman with acute promyelocytic leukemia with the typical t(15;17) translocation, but with a second c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000